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It is important to note that impaired motor activity and fatigue can also be associated with antihistamine use, and this should be considered when selecting the appropriate AR medication.In patients previously sensitized to specific aeroallergens, subsequent exposure induces an immunoglobulin E–mediated biochemical cascade resulting in mast cell/basophil degranulation and release of inflammatory mediators.The effects of fexofenadine, diphenhydramine, alcohol, and placebo were assessed in a randomized, double-blind, 4-treatment, 4-period crossover trial of 40 licensed drivers with seasonal AR aged 25 to 44 years.

Participants demonstrated similar performance with placebo and fexofenadine.

Driving performance was the worst with diphenhydramine.

They are appropriate for use in the pediatric population, and 3 products, Allegra, Claritin, and Zyrtec, are FDA-approved as liquid formulations for use in children 2 years and older.

Dosage information for OTC second-generation antihistamines is listed in the Table.

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When you have an allergic reaction, your body releases a substance called histamine.

Because Allegra provides powerful efficacy in AR without the risk of sedation, it is a good first choice when making recommendations in this class.

Good Rx is not available outside of the United States.

While an individual’s response to allergens varies, OTC therapies can offer an effective initial approach to treatment, should allergen avoidance be difficult or impractical.

PHARMACOLOGY OF ANTIHISTAMINES Antihistamines used to treat AR are competitive antagonists for histamine-1 (H Both first- and second-generation antihistamines alleviate AR symptoms or other upper respiratory allergies.

Histamine causes allergy symptoms when it binds to receptors on certain cells in your body.

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